With strategies such as Transcranial Magnetic Stimulation (TMS), Ketamine, and psychedelics becoming more prevalent for treatment-resistant depression, it is helpful to take a look at what this entity really means. Not everyone who is being referred for either TMS or treatment with Ketamine may have "true" treatment-resistant depression, and then there is what is called "pseudo-resistance." In simple terms, treatment-resistant depression implies that depression has not reached sufficient remission after adequate treatment. Remission is defined as clinical improvement with few signs of depression still remaining and a lower likelihood of subsequent exacerbations. About 15% of people with depression may eventually develop treatment-resistant depression (Berlim & Turecki, 2007). Treatment-resistant depression has been variously defined, but the most commonly accepted definition is as follows (Souery et al., 2007): A person with depression is considered ...
Authored by Dr. Harpreet Duggal, a board-certified psychiatrist and expert in self-managing depression, this blog offers practical strategies for treating depression beyond medications and therapy. It explores key elements such as healthy living, positive psychology, relationships, personal values, strengths, communication, and overall wellness. Please note that this blog is for informational purposes only and should not be considered professional treatment advice.